Fumonisins acts as an inhibitor of ceramide synthase and prevents the biosynthesis of membranes. In humans, fumonisin is linked with esophageal cancer. In animals including horses, swine, poultry and cattle it has caused everything from heart and liver damage to impaired growth and kidney and liver cancer. Like other mycotoxins, fumonisin poses dangers to animals and humans through the food, feed and pet food supply chains. Corn and small grains such as wheat, oats and barley are the major crops affected.
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